Mickelson, 48, boosted his goal of competing in France later this month in posting closing rounds of 67 and sizzling final round 63 for an eventual 10-under par total and a share of 12th place.
Mickelson had faced an anxious wait late on Saturday before the assurance his two-over 36-hole effort was good enough to make the cut right on the two-over mark.
Now Mickelson is a near certainty to be heading to France and being a member of a USA Team looking to win on European soil for a first occasion in 25-years.
“Well, this one has an opportunity to be my favourite and most special,” said Mickelson.
“We’ve never won over there. I feel like we have the team. I feel like we have the leadership and we have the direction.
“We have the game plan that will allow us to play our best.
“If I’d be lucky enough to get on the team and go over there and be part of a winning team it would probably be my most memorable one.”
Mickelson made his Ryder Cup debut in 1995 and has competed in the event ever since teeing-up in 45 matches.
He enjoys a record of 18 wins, 20 losses and seven half-points.
In contrast, it is Spain’s Rafa Cabrera-Bello who faces an anxious few days before knowing if he will earn a second straight European Team cap.
Cabrera-Bello had thought of travelling to Denmark last week and boost his chances of qualifying via the final selection event on the European Tour but instead remained in the States to compete in Boston.
The Dubai-based Spaniard went close to a first PGA Tour victory when he moved into a share of the lead with a fourth birdie in succession at the 11th hole and racing to be six-under for his last round.
However, Cabrera-Bello dropped three shots over his closing six holes in a round of 68 to eventually share seventh place at 11-under par.
“I’ve done everything I can,” he said.
“I love the Ryder Cup. It would be a huge honour to represent my continent again. And I would be 100 percent availability if he needs me.
“I do understand it’s a difficult pick because there are lots of good players outside.
“But I feel like even in my best chance, if he was trying to see if I was in form or not, I think this week proves that I am.”
European Team captain Thomas Bjorn will announce all four ‘captain’s’ picks at 2pm UK time on Wednesday.